3754 Brevard Road, Suite 116, Box 19
Horse Shoe, North Carolina 28742-8814 USA
Phone: (828) 891-5637; Fax: (828) 890-8130


The goal of the Institute is to explore the interfaces of fundamental biological science, clinical science, and clinical care with a special emphasis on targeted cancer therapy. The current focus centers on signaling by protein kinases. These enzymes (protein kinases) play a key regulatory role in nearly every aspect of cell biology. Owing to the myriad actions of protein kinases, it is imperative that they be stringently regulated because aberrant activity of these enzymes can lead to a variety of diseases including, inter alia, cancer, diabetes and autoimmune, cardiovascular, degenerative, inflammatory, and nervous disorders. Because mutations and dysregulation of protein kinases play causal roles in human disease, these enzymes represent attractive drug targets. Our research focuses on the epidermal growth factor receptor protein-tyrosine kinase, Raf/Mek/Erk protein kinases, and on the regulation of tyrosine hydroxylase activity by protein phosphorylation. 

To contact us by e-mail: Webmaster@brimr.org. Thank you for visiting this site, which is accessed from more than 75 countries each month.

Research is the hardest and finest game. –  Ernest Henry Starling.
Medicine evolved from a therapeutic art into a therapeutic science,
based on a reductionist approach derived from biochemistry and later
from molecular biology.  Eric R. Kandel
It is nice to know that the computer understands the problem,
but I would like to understand it too. – Eugene P. Wigner
When you get to a fork in the road, take it. – Yogi (Lawrence Peter) Berra
Robert Roskoski Jr. MD, PhD. Institute Research Goals News Items
Scientific Director. 

Background, Robert Roskoski Sr. circa 1940

Officers and Directors; Institute Bylaws

Book and Journal covers

To zoom in, right click on the photo and select View Image.

Properties of USFDA approved drugs that inhibit protein kinases

Life Science Sketches

North Carolina Photos
 e-mail: rrj@brimr.org


NIH Funding Rank of US Medical Schools from 2006-2016

Protein Kinase and Phosphatase Research Sites

Common Sense Health Tips

The Blue Ridge Institute for Medical Research is a Federal tax exempt 501(c)(3) non-profit organization incorporated in the State of North Carolina on 24 March 2006 (EIN 20-4665742; DLN 17053144012016).

Updated 14 January 2016

Visitors since 7 August 2010